Topological Data Analysis for Ring Channels in Cells

WAKE FOREST UNIVERSITY
DEPARTMENT OF MATHEMATICS & STATISTICS

Presents

Veronica Ciocanel
The Ohio State University

Thursday, October 31st, 2019
11am
Carswell Hall, Room 101

Abstract: Ring channels are structures made of linked protein polymers (filaments) that are important in development, wound healing, and cell division. In the reproductive system of the worm model organism, ring channels promote nutrient exchange to developing egg cells and are regulated by forces from motor proteins.

I will present a modeling and data analysis framework for the interactions between filaments and motor proteins inside cells. This agent-based modeling approach may provide key insights for the differences between two motors that are believed to maintain rings open at a constant diameter. In particular, we propose tools drawing from topological data analysis to understand time-series data of filament interactions. Our method reveals the impact of certain parameters on significant topological circle formation, thus giving insight into ring channel formation and maintenance in this biological system.

Comments are closed.